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COLCHICINE
Generic Name : COLCHICINE
ABSTRACT -
Colchicine is an anti-gout agent drug that is generally used to treat gout in adults by altering body responses to increased levels of uric acid crystals that are responsible for swelling and pain. This drug and certain other variations of the same are also used to treat symptoms of the Behcet’s syndrome, gout attacks, and even a condition known as Familial Mediterranean Fever. This medication is known for its quality of being a preventive anti-gout agent. Certain brands of this drug are not approved by the FDA.
DOSAGE –
- Colchicine is to be taken as directed by the doctors.
- Can be taken immediately at the sight of an attack.
- During a gout attack, a second dose may be required an hour later, in case of pain.
- General Adult Dosage available: Oral tablet – 0.5mg, 0.6mg Solution – 0.5mg/mL
SIDE EFFECTS –
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
RARE SIDE EFFECTS:
- Bloody diarrhea
- Shortness of breath during exercise
- Numbness in the fingers and toes
- Severe headaches
- Sore throat
- Ulcers/white spots in the mouth
- Easy bruising/bleeding
- Severe fever
- Chills
DRUG INTERACTIONS –
- Amiodarone
- Amprenavir
- Atazanavir
- Azithromycin
- Boceprevir
- Carvedilol
- Clarithromycin
- Cyclosporine
- Dronedarone
- Fosamprenavir
- Indinavir
- Ketoconazole
- Ulipristal
MODERATE DRUG INTERACTIONS –
- Adalimumab
- Azathioprine
- Cabazitaxel
- Clofibrate
- Deferasirox
- Eribulin
- Etravirine
- Golimumab
- Paclitaxel
- Zafirlukast
PRECAUTIONS –
- Provide the doctor with a detailed and accurate medical history prior to drug prescription. Notify especially in case of liver/kidney disease or consumption of medications such as digoxin, HIV/AIDS medications, nefazodone, itraconazole/ketoconazole, clarithromycin or telithromycin.
- Cooperate with frequent medical tests in case of long-term use of this drug.
- Do not nurse while on drug course, as this drug may transfer through breast milk.
- Avoid grapefruit while on drug course.
WARNINGS –
- Keep out of reach of children.
- Each brand of Colchicine may be used to treat different kinds of illnesses. Consult with the doctor regarding which brand of Colchicine would be recommended to treat the patient.
- This drug does not cure gouty arthritis or Behcet’s syndrome, but can be used as preventive medication to avoid gout attacks.
- In case of overdose, get medical help or contact a Poison Control Center immediately as it may be fatal. Symptoms of overdose may include – severe diarrhea, vomiting, abnormal change in urination, weak pulse, extremely shallow breathing or fainting.
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