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ARMODAFINIL
Generic Name: ARMODAFINIL
ABSTRACT -
Armodafinil is the R-enantiomer of modafinil and is a wakefulness-promoting medicine. It is used in adults for excessive sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is not a replacement for treating airway obstruction in obstructive sleep apnea and does not cure the underlying sleep disorder.
DOSAGE -
- Dosage should be determined only by a qualified healthcare professional.
- For narcolepsy or obstructive sleep apnea, common labeled adult dosing is 150-250 mg orally once daily in the morning.
- For shift work disorder, common labeled adult dosing is 150 mg orally about 1 hour before the work shift.
- Dose reduction should be considered in severe hepatic impairment and cautious dosing is advised in older adults.
SIDE EFFECTS–
- Headache, nausea, dizziness, insomnia, anxiety, dry mouth, or decreased appetite
- Palpitations, increased blood pressure, chest discomfort, or psychiatric symptoms
- Rash, urticaria, angioedema, or severe skin reactions including Stevens-Johnson syndrome rarely
- Mania, hallucinations, aggression, suicidal ideation, or serious psychiatric worsening
- Potential dependence/misuse risk because it is a controlled substance in some jurisdictions
ALLERGIC REACTIONS -
- Stop armodafinil and seek urgent care if rash, mucosal lesions, facial swelling, trouble breathing, or fever with systemic symptoms occurs.
- Serious hypersensitivity and multi-organ hypersensitivity have been reported with modafinil/armodafinil class products.
DRUG INTERACTIONS–
- Hormonal contraceptive effectiveness may be reduced; additional contraception is recommended during treatment and for a period after stopping.
- CYP3A4 substrates, CYP2C19 substrates, warfarin, diazepam, phenytoin, omeprazole, and some antidepressants may require monitoring.
- Alcohol and other CNS-active medicines can impair judgment or increase adverse effects.
- Avoid combining with other stimulants without clinician supervision.
PREAUTIONS–
- Evaluate cardiovascular disease, hypertension, psychiatric history, sleep-disorder diagnosis, pregnancy status, and substance-use risk before treatment.
- Monitor blood pressure, heart rate, sleepiness, psychiatric symptoms, rash, and misuse.
- Continue CPAP or other primary OSA therapy when prescribed.
- Avoid driving or hazardous work until individual response is known.
WARNINGS –
- Serious rash or hypersensitivity requires immediate discontinuation.
- Psychiatric symptoms, chest pain, arrhythmia, or severe hypertension require urgent evaluation.
- Do not use to overcome normal sleep deprivation.
- Keep out of reach of children.
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