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ALEFACEPT
Generic Name: ALEFACEPT
ABSTRACT -
Alefacept is an immunomodulatory biologic formerly used for chronic plaque psoriasis in some jurisdictions. Availability is limited and current local regulatory status must be confirmed.
DOSAGE -
Use the current locally approved prescribing information where a product is authorized. For investigational products, dose, route, schedule, premedication, and dose modifications must come only from the applicable clinical-trial protocol. No dose should be selected from this summary.
SIDE EFFECTS–
- Injection reactions
- Headache
- Upper respiratory infection
- Reduced lymphocyte counts
- Dizziness
- Malignancy or serious infection risk
ALLRGIC REACTIONS–
(These symptoms may indicate a serious allergic or infusion reaction and require medical attention.)
- Hives or a rapidly spreading rash
- Swelling of the face, lips, tongue, or throat
- Wheezing, breathing difficulty, or sudden dizziness
- Severe blistering, mucosal lesions, or anaphylaxis
DRUG INTERACTIONS–
- Other immunosuppressants may increase infection risk
- Live vaccines may be inappropriate
PREAUTIONS–
- Monitor CD4 lymphocyte counts where required
- Screen for infection and malignancy risk
WARNINGS –
- Clinically important lymphopenia and serious infection can occur
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