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ACOTIAMIDE
Generic Name: ACOTIAMIDE
ABSTRACT -
Acotiamide is an approved gastroprokinetic agent used for the treatment of functional dyspepsia. It acts as an acetylcholinesterase inhibitor and muscarinic M1/M2 receptor antagonist, enhancing gastric motility and improving upper gastrointestinal symptoms. It is approved in Japan and several Asian countries for postprandial distress syndrome.
DOSAGE -
Acotiamide standard adult dose: 100 mg three times daily, taken before meals. Not approved for pediatric use. Dose adjustment may be needed in elderly or patients with hepatic impairment. Duration of treatment typically 4 weeks, reassessed based on clinical response.
SIDE EFFECTS –
Reported or potential side effects may include:
- Diarrhea
- Constipation
- Abdominal distension
- Headache
- Dizziness
- Elevated liver enzymes
- Nausea
ALLRGIC REACTIONS–
(These symptoms may indicate an allergic reaction to the drug.)
- Skin rash
- Itching
- Hypersensitivity reactions
- Urticaria
DRUG INTERACTIONS–
- Anticholinergic drugs (opposing effect)
- Acetylcholinesterase inhibitors (additive effects)
- Drugs metabolized by CYP3A4
PREAUTIONS–
- Monitor liver function during prolonged use.
- Use with caution in patients with hepatic impairment.
- Safety in pregnancy and breastfeeding not established.
- Not recommended in patients with gastrointestinal obstruction.
- Inform physician of all concurrent medications.
WARNINGS –
- Hepatic dysfunction has been reported.
- Discontinue if severe liver enzyme elevations occur.
- Not indicated for use in children.
- Keep out of reach of children.
- Seek medical attention if symptoms worsen.
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