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ALFACALCIDOL
Generic Name: ALFACALCIDOL
ABSTRACT -
Alfacalcidol is converted in the liver to active calcitriol and is used to manage selected disorders of calcium and bone metabolism, especially when renal activation of vitamin D is impaired.
DOSAGE -
Use the current locally approved prescribing information where a product is authorized. For investigational products, dose, route, schedule, premedication, and dose modifications must come only from the applicable clinical-trial protocol. No dose should be selected from this summary.
SIDE EFFECTS–
- High calcium
- High phosphate
- Nausea or constipation
- Weakness
- Kidney stones
- Itching or rash
ALLRGIC REACTIONS–
(These symptoms may indicate a serious allergic or infusion reaction and require medical attention.)
- Hives or a rapidly spreading rash
- Swelling of the face, lips, tongue, or throat
- Wheezing, breathing difficulty, or sudden dizziness
- Severe blistering, mucosal lesions, or anaphylaxis
DRUG INTERACTIONS–
- Thiazide diuretics may increase hypercalcaemia risk
- Digoxin toxicity may be promoted by hypercalcaemia
- Magnesium-containing antacids require caution in renal disease
PREAUTIONS–
- Monitor calcium, phosphate, kidney function, and parathyroid hormone
- Adjust calcium and phosphate intake as directed
WARNINGS –
- Excess dosing can cause prolonged hypercalcaemia and renal injury
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