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ALGLUCOSIDASE
Generic Name: ALGLUCOSIDASE
ABSTRACT -
Alglucosidase alfa replaces deficient lysosomal acid alpha-glucosidase in Pompe disease. It is administered by intravenous infusion under specialist supervision.
DOSAGE -
Use the current locally approved prescribing information where a product is authorized. For investigational products, dose, route, schedule, premedication, and dose modifications must come only from the applicable clinical-trial protocol. No dose should be selected from this summary.
SIDE EFFECTS–
- Infusion reactions
- Fever or chills
- Rash
- Breathing difficulty
- Changes in blood pressure
- Development of anti-drug antibodies
ALLRGIC REACTIONS–
(These symptoms may indicate a serious allergic or infusion reaction and require medical attention.)
- Hives or a rapidly spreading rash
- Swelling of the face, lips, tongue, or throat
- Wheezing, breathing difficulty, or sudden dizziness
- Severe blistering, mucosal lesions, or anaphylaxis
DRUG INTERACTIONS–
- No major metabolic interactions are expected, but other infusion therapies may complicate reactions
PREAUTIONS–
- Monitor during and after infusions
- Assess cardiac and respiratory status
- Manage immunogenicity according to specialist guidance
WARNINGS –
- Severe anaphylaxis and infusion-associated cardiorespiratory reactions can occur
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