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CADROFLOXACIN
Generic Name: CADROFLOXACIN
ABSTRACT -
Cadrofloxacin is a novel-generation fluoroquinolone antibiotic with enhanced activity against respiratory pathogens including drug-resistant Streptococcus pneumoniae and Staphylococcus aureus. It inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication. It is being evaluated for community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).
DOSAGE -
Oral or intravenous formulations under evaluation; once-daily dosing regime being studied in Phase II/III clinical trials.
SIDE EFFECTS -
- Nausea
- Diarrhoea
- Headache
- Dizziness
- QTc prolongation
ALLERGIC REACTIONS -
These symptoms may indicate an allergic reaction and require immediate medical attention.
- Skin rash
- Photosensitivity reactions
- Drug reaction with eosinophilia and systemic symptoms (DRESS)
- Anaphylaxis
DRUG INTERACTIONS-
- Divalent cations (antacids, iron, zinc) impair absorption — separate by 2 hours
- QTc prolongation risk with antiarrhythmics, antipsychotics, macrolides
- NSAIDs may lower seizure threshold in combination with fluoroquinolones
PREAUTONS–
- Avoid in patients with known QT prolongation or hypokalaemia
- Tendon rupture risk — especially in elderly and corticosteroid users
- CNS adverse effects may impair driving ability
- Avoid in pregnancy — cartilage toxicity in developing joints
WARNINGS –
- Aortic aneurysm and dissection risk — class fluoroquinolone warning
- Tendinitis and tendon rupture — discontinue at first sign of tendon pain
- Peripheral neuropathy — may be irreversible; discontinue if symptoms develop
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