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ALECTINIB
Generic Name: ALECTINIB
ABSTRACT -
Alectinib inhibits ALK and RET kinases and is used in selected ALK-positive non-small-cell lung cancer settings.
DOSAGE -
Use the current locally approved prescribing information where a product is authorized. For investigational products, dose, route, schedule, premedication, and dose modifications must come only from the applicable clinical-trial protocol. No dose should be selected from this summary.
SIDE EFFECTS–
- Constipation
- Fatigue
- Muscle pain
- Oedema
- Liver-enzyme elevation
- Bradycardia or interstitial lung disease
ALLRGIC REACTIONS–
(These symptoms may indicate a serious allergic or infusion reaction and require medical attention.)
- Hives or a rapidly spreading rash
- Swelling of the face, lips, tongue, or throat
- Wheezing, breathing difficulty, or sudden dizziness
- Severe blistering, mucosal lesions, or anaphylaxis
DRUG INTERACTIONS–
- Medicines causing bradycardia may have additive effects
- Review hepatotoxic medicines
- Metabolic interactions should be assessed using the current label
PREAUTIONS–
- Monitor liver tests, heart rate, muscle symptoms, and lung symptoms
- Use sun protection because photosensitivity can occur
WARNINGS –
- Hepatotoxicity, pneumonitis, severe myalgia, and bradycardia can occur
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