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BUROSUMAB
Generic Name: BUROSUMAB
ABSTRACT -
Burosumab is a human monoclonal antibody that binds and inhibits FGF23. It is used for disorders of phosphate wasting such as X-linked hypophosphatemia and selected cases of tumor-induced osteomalacia where approved.
DOSAGE -
Burosumab is administered by subcutaneous injection under specialist supervision.
- Dosing is individualized according to indication, body weight, serum phosphate, and clinical response.
- Serum phosphate and renal status should be monitored during treatment.
SIDE EFFECTS-
Common or possible side effects may include:
- Injection-site reaction
- Headache
- Pain in arms or legs
- Fever
- Rash
- Tooth or bone discomfort
- High phosphate levels
- Hypersensitivity reactions
Serious adverse effects depend on dose, route, indication, comorbidities, and concomitant medicines.
ALLERGIC REACTIONS -
Burosumab may cause allergic or hypersensitivity reactions. Risk may be higher in patients with previous reactions to related products or excipients.
Symptoms may include:
- Fever
- Skin rash
- Itching
- Hives
- Swelling of face, lips, tongue, or throat
- Wheezing or shortness of breath
- Severe dizziness
- Low blood pressure
- Anaphylaxis in severe cases
Important: Stop treatment and seek urgent medical help if a serious allergic reaction is suspected.
DRUG INTERACTIONS-
Burosumab may interact with certain medicines or substances. Caution is needed with:
- Other immunomodulatory medicines
- Live vaccines where immune function may be affected
- Myelosuppressive anticancer therapies
- Corticosteroids or immunosuppressants when clinically relevant
Patients should inform healthcare providers about all prescription medicines, over-the-counter medicines, herbal products, and supplements they are using.
PREAUTONS–
- Monitor fasting serum phosphate as directed.
- Avoid concurrent oral phosphate or active vitamin D unless directed.
- Assess renal status and risk of ectopic mineralization.
- Monitor for hypersensitivity and injection-site reactions.
WARNINGS –
- Excess phosphate elevation may increase risk of ectopic mineralization.
- Monitor phosphate and renal status as directed.
- Serious hypersensitivity reactions require immediate medical attention.
- Use only under specialist supervision.
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